Class: EvidenceLine

A discrete, independent argument relevant to the validity of the Proposition put forth as true in the Statement, that is based on the interpretation of one or more pieces of information as evidence.

URI: vaspec:EvidenceLine

Parents

• is_a: InformationEntity - An abstract (non-physical) entity that is about something.

Referenced by Class

• Statement Statement➞hasEvidenceLine _0..* EvidenceLine

Attributes

Own

• EvidenceLine➞evidenceLineType _0..*
  • Description: A more specific type of evidence line this object may represent (e.g. 'mutant phenotype evidence', 'evidence from manual interpretation', 'ACMG PM2 evidence')
  • Range: Coding
• EvidenceLine➞targetProposition _0..1
  • Description: The proposition against which the evidence items were evaluated, in determining the overall strength and direction of evidence they provide (as captured in the Evidence Line)
  • Range: Proposition
• EvidenceLine➞hasEvidenceItem _0..*
  • Description: An Information Entity that supports the argument that the Evidence Line Represents.
  • Range: InformationEntity
• EvidenceLine➞evidenceDirection _0..1
  • Description: The direction of support that the Evidence Line is determined to provide for its target Proposition (can be supporting, disputing, or neutral)
  • Range: Coding
• EvidenceLine➞evidenceStrength _0..1
  • Description: The strength of support that an Evidence Line is determined to provide for or against its target Proposition.
  • Range: Coding
• EvidenceLine➞evidenceItemSource _0..*
  • Description: An information resource (e.g. document, dataset, knowledgebase) that provided information interpreted as evidence in building an Evidence Line.
  • Range: InformationEntity

Inherited from InformationEntity:

• Element➞extensionElement _0..*
  • Description: A key-value data structure that allows definition of custom fields to capture information not directly supported by the VA specification.
  • Range: Extension
• Entity➞localId _1..1
  • Description: The 'logical' identifier of the entity in the system of record, e.g. a UUID. This 'id' is unique within a given system. The identified entity may have a different 'id' in a different system.
  • Range: Identifier
• Entity➞globalIdentifier _0..*
  • Description: A 'business' identifier or accession number for the entity, typically as provided by an external system or authority, that is globally unique and persists across implementing systems.
  • Range: Identifier
• Entity➞type _1..1
  • Description: The schema class that is instantiated by the data object. Must be the name of a class from the VA schema.
  • Range: Class
• Entity➞label _0..1
  • Description: A primary name for the Entity.
  • Range: Ga4ghString
• Entity➞alternativeLabel _0..*
  • Description: An alternative name for the Entity.
  • Range: Ga4ghString
• Entity➞description _0..1
  • Description: A free text description of the Entity.
  • Range: Ga4ghString
• Entity➞hasURL _0..*
  • Description: The URL/web address of a digital resource representing the entity, or providing information about it.
  • Range: Url
• Entity➞reference _0..*
  • Description: A document or other Information Entity that describes the Entity.
  • Range: InformationEntity
• Entity➞xref _0..*
  • Description: A cross-reference that links to database identifiers of an entity that represents the same or a closely related concept or knowledge as the Entity.
  • Range: Ga4ghString
• Entity➞thisRecordMeta _0..1
  • Description: A reusable structure that encapsulates provenance metadata that applies to this concrete record/encoding of information about the Entity.
  • Range: RecordMetadata
• Entity➞sourceRecordMeta _0..*
  • Description: A reusable structure that encapsulates provenance metadata that applies to an upstream data record about the Entity, from which content of the present record was derived.
  • Range: RecordMetadata
• InformationEntity➞isAbout _0..*
  • Description: An entity or concept in the world that the information entity describes/is about.
  • Range: Entity
• InformationEntity➞qualifiedContribution _0..*
  • Description: A specific contribution made by some Agent to the creation, modification, or validation of the information represented in the Information Entity.
  • Range: Contribution
• InformationEntity➞dateAuthored _0..1
  • Description: The date the information content expressed in this entity was generated.
  • Range: Ga4ghDateTime
• InformationEntity➞wasSpecifiedBy _0..*
  • Description: A plan specification that describes all or part of the process through which the information was generated.
  • Range: Method
• InformationEntity➞derivedFrom _0..*
  • Description: An information resource from which the Information Entity is derived, in whole or in part
  • Range: InformationEntity
• InformationEntity➞wasOutputOf _0..*
  • Description: An activity that generated the Entity.
  • Range: Activity
• InformationEntity➞hasPart _0..*
  • Description: Any part of the Information Entity (e.g. individual value or record from a larger data set, a section of a larger document)
  • Range: InformationEntity
• InformationEntity➞partOf _0..*
  • Description: A larger Information Entity of which the present Information Entity is a part.
  • Range: InformationEntity
• InformationEntity➞isReportedIn _0..*
  • Description: A document in which the information content carried by the Information Entity is expressed
  • Range: Document
• InformationEntity➞confidenceLevel _0..1
  • Description: A qualitative term describing of degree of confidence held by the creator of the information entity, that the information it represents is true (e.g. 'high confidence', 'likely true', 'low confidence').
  • Range: Coding
• InformationEntity➞confidenceScore _0..1
  • Description: A quantitative score reflecting the degree of confidence held by the creator of the information entity, that the information it represents is true.
  • Range: DataItem
• InformationEntity➞version _0..1
  • Description: The version of the Information Entity (to be used in cases where version is not reflected in the id or identifiers associated with the entity).
  • Range: Ga4ghString
• InformationEntity➞license _0..1
  • Description: The type of license that dictates legal permissions for how a resource (e.g. dataset, document, protocol) can be used - typically referenced by its URL.
  • Range: Ga4ghString

Other properties

Comments:		Evidence Lines result from the interpretation of one or more pieces of information (Evidence Items) to build an argument for or against a particular Proposition (possible fact). The Evidence Line that results can be considered a special kind of Statement that asserts the direction and strength such an argument provides for some target Proposition. For example, The various allele counts and frequency calculations for the BRCA2 c.8023A>G variant found in the ExAC database are Evidence Items that might be collectively assessed by a ClinGen curator to build an Evidence Line that is deemed to 'support' with 'moderate' strength a target proposition that the variant is pathogenic for Breast Cancer. The narrative form of the Statement represented by this Evidence Line is roughly: "ExAC allele frequency data for BRCA2 c.8023A>G {0.0000021, 0.0000034, ...} provides evidence of moderate strength supporting the proposition that BRCA2 c.8023A>G is pathogenic for Breast Cancer".
Exact Mappings:		SEPIO:0000002